Histopathological, Endocrine & Immunological Assessment of Rainbow Trout Exposed to Kimberlite Ore Tailings (GLOBALTOX, July 1998)
This multi-part final report documents a dose-response study of rainbow trout exposed to kimberlite ore tailings at 50 and 500 mg/L concentrations over 15 and 30 days, assessing histopathological changes in gills, liver and kidney, serum hormone levels (cortisol, estradiol, testosterone), and immunological parameters including phagocytic function and lymphoproliferation. The studies collectively demonstrate that kimberlite exposure caused adverse effects at all tested concentrations, with LOEC/LOAEC estimated below 50 mg/L, and immunomodulatory effects dependent on dose and exposure duration.
- Date
- Document type
- Report
- Parties
- GLOBALTOX INTERNATIONAL CONSULTANTS INC., EnviroTest Laboratories Ltd., HydroQual Laboratories Ltd., BHP Canada, Dr. Dieb Birkholtz, New York University School of Medicine, University of Saskatchewan, Judith T. Zelikoff, Tracy A. Marchant, Dr. Ansar Qureshi
- Locations
- Edmonton, Alberta, Ottawa, Ontario, Calgary, Alberta, Tuxedo, New York, Saskatoon, Saskatchewan
- Parameters
- histopathology, fish gill health, liver pathology, kidney pathology, kimberlite ore exposure, apoptosis, edema, lamellar fusion, cortisol, 17-beta-estradiol, testosterone, immunological function, phagocytic activity, white blood cell counts, hematocrit, leukocrit, immunoglobulin levels, lymphoproliferation, dose-response, NOEC, NOAEC, LOEC, LOAEC
- Pages
- 75
Original document
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